Another clinical study published in Ophthalmology, this one led by Crandall Peeler, MD, of Boston Medical Center, examined oral sedation versus intravenous sedation. 85 patients were randomized to receive either oral triazolam with IV placebo or IV midazolam with oral placebo preoperatively.

The primary outcome was patient satisfaction, measured by a survey administered on postoperative day one. Secondary outcomes included surgeon and anesthesia provider satisfaction, need for supplemental anesthesia, and surgical complications.

Mean patient satisfaction score was 5.34 ± 0.63 (range 3.75 to 6) in the oral sedation group and 5.40 ± 0.52 (range 4 to 6) in the IV group. Eight patients in the oral group (19.0%) and 3 in the IV group (7.0%) received supplemental IV sedation. Read the full study here.